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Istradefylline forty mg/day greater peak concentrations and AUC of CYP3A4 substrates in medical trials. This result was not observed with istradefylline 20 mg/working day. Take into account dose reduction of sensitive CYP3A4 substrates.Outcome of coadministration of the twin CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been researched.Our ev